In 1918, an English family are terrorized by a vampire, until they learn how to deal with it. They think their troubles are over, but German bombs in WWII free the monster. He reclaims the soul of his wolfman ex-servant, and assuming the identity of a scientist who has just escaped from a concentration camp, he starts out on a plan to get revenge upon the family.

In the small town of Stone Cove, Maine, deputy sheriff Dwayne Hopper is on the night shift at the police station. He discovers that one of the prisoners in the holding cell is Ronald Perkins, a local psychiatrist and a suspect in the disappearance of 14 children over the past 10 years, including Hopper's young son. Interrogating Perkins, Hopper learns that the mad psychiatrist has built an army of 14 people brainwashed through cult-like methods to protect him from Perkins' parents' killers. Investigating, Hopper and the police unwittingly unleash his followers on the small town, and a night of terror beings as the 14 super-strong, zombie-like warriors wreck havoc with only one thing on their mind: "Kill for Mr. Perkins."

In Las Vegas, the powerful three hundred year old vampire Sylvian hires Dr. van Helm to research a cure to survive in the sun. She uses three vampire women as guinea pigs to test the serum in the desert and a couple that is camping witnesses the failure and calls the police. Detective Stanton and his partner Detective O'Hara are assigned to investigate the case. Meanwhile, Jason, who is going to marry Rachel, and two friends travel to Las Vegas for his bachelor party with a couple of strippers, but the women are actually vampires that attack them. Out of the blue, Rachel and her friend Nikki decide to travel to Las Vegas to surprise her boyfriends. The group is captured by Sylvian that uses them to feed the pack vampires and test the new research.

The place is Helverton, Colorado, a town of about 350,000 people. 15-year-old Genevieve Gage and her best friend Tiana Moore are typical teenagers who spend a lot of time surfing the internet and sending messages to strangers in chat rooms. Upon "meeting" another apparent student who goes by the screen name of Captain Howdy, Genevieve and Tiana decide to attend a party at Captain Howdy's house. As it turns out, Captain Howdy has lured them into a darkness from which there may be no permanent escape. But what Captain Howdy doesn't know is that Genevieve's father is local cop Mike Gage. When neither Genevieve nor Tiana has returned home by the next morning, Genevieve's mother Toni alerts Mike. With the help of a younger cop named Steve Christian, Mike tries to find Genevieve and Tiana. Things take an unexpected turn when Tiana's car is pulled out of a lake...