In the year 2310, a new sport, GENE-FUSION is all the rage! In this exciting game, specially-trainer athletes, called Fusers, design their own super-creature by combining three forms of animal DNA... Four teens, seemingly plucked from obscurity, are trained to be Fusers. They become instant celebrities they perform before sold out crowds. But what hey don't know is that each of them has a role to play in an alien conspiracy to take over the world. Only through learning to work together as a team can these four young heroes take on this alien threat and save the planet from destruction.

The Evangelion saga from TV is artfully recounted, with some additional scenes, in part one see: "Shin Seiki Evangelion" (1995) Part two starts immediately afterward, where the NERV organization has outlived its usefulness. The shadowy covenant of SEELE launches an all-out commando assault against the ill-defended headquarters. Asuka, semi-comatose, is placed in her EVA for safety, while Misato and company struggle to find Shinji and Rei before they're assasinated by SEELE's forces.

Boston, 2009. A police detective (Roddy Piper) searches for Adrian Dunn, his ex-partner (Billy Drago) who murdered his wife. Dunn has escaped from prison on the moon and returned to Earth with an alien virus.