Following an ace assassin who is double crossed by gangsters and falls into the hands of rogue surgeon known as The Doctor who turns him into a woman. The hitman now a hitwoman sets out for revenge, aided by a nurse named Johnnie who also has secrets.

Ashley goes to her new college while getting over the death of her mother. She meets some new people there including Binder ('Shane Dawson' ) while at a party and she learns about an urban legend of an online killer that has the nickname "Smiley" who can only be seen on the web and he apparently kills people after they type in "I did it for the lulz" three times. Soon after going to the party Ashley and her flatmate Proxy go online to test it out, with horrific results. She becomes paranoid and she starts to think she sees Smiley all over the place and feels that he may be chasing her, but how can that be if he is not real? Have they somehow released him from the internet?