Arthur Bishop, the master assassin who faked his death in hopes of putting that part of his ;life behind him, now lives a quiet life in Rio. But someone who knows who he is shows up and tells him, that if he wants to continue living this life, he will do three jobs for someone. Bishop tries to tell them he has the wrong man but they know who he is and if he won't do the job, they will take him but he gets away. He then goes to a resort in Thailand run by a friend, Mae, where he tries to find out...

26 men are chosen to participate in the roles of guards and prisoners in a psychological study that ultimately spirals out of control.