Obsessed with day-time TV soaps, Ekta Santoshi starts suspecting her husband, Gopal, of having an affair with an unknown woman. Not satisfied with his explanations, she decides to investigate, setting off a chain of hilarious events. These involve her dumb brother/hair-stylist, Lucky; her sister-in-law, Esha, who loves ACP Madhav Singh Ghai; two individuals both named Anthony Gonsalves; amongst many others that result in a hapless Gopal's arrest for the homicide of his co-worker, Subodh Mehra.

When Meghalaya-based Gogai attempts to molest his subordinate, Kalyani, her husband, Khogiram Maheshwar Gwala, also an employee, intervenes, a scuffle ensues, people gather and separate the duo, and an enraged Gogai fires them. Khogiram is unable to find a job; Kalyani does not make enough money weaving baskets; while their two children, Pinaki and Rimzim, have not only to deal with their respective Catholic schools, but also assist their parents, and share a pair of shoes. Things get even worse after Gogai gets killed, and Inspector Vishwajeet Khatonyar detains and interrogates Khogiram - suspecting him of not only killing Gogai but also having connections with terrorists.

Born in West Bengal, Subhrojeet Chakraborty re-locates to Mumbai, to work with Lalaji Telefilms as a Creative Head Director. He meets with the Executive Director, Anekta Kapoor, and after going through various formalities - including having his Kundali/Astrological Chart approved - he is hired and instructed to increase the firm's TRP's with a good day-time soap. With all ideas already being telecast by Ekta Kapoor and Balaji Telefilms, he is at a loss and encounters writers' block. This issue resolves itself after he meets with his neighbor, Sumana Roy Chowdhury, and decides to write a story about the two of them. His work is accepted, initial episodes are telecast, and the ratings do surge upwards - but not for long - as soon Sumana finds out, confronts him, the duo find they are attracted to each other and get married. The question remains: with the two getting married, how will the show and the remainder of the episodes proceed?

Housefull is a romantic comedy entertainer which narrates the story of Aarush - the world's unluckiest man. Being jinxed, he believes his bad luck can vanish if he finds true love. In this quest for true love how one lie leads to another and how different people from different walks of life come together adding even more confusion to this hilarious comedy of errors resulting in total chaos and mayhem forms the crux of the story. The line which Deepika tells Akshay in the film "Jis jhooth se kissi ka ghar basta ho, voh jhooth jhooth nahin hota", pretty much sums up the essence of the film.