A military weapons manufacturer creates a chemical weapon that causes victims to become blood-lusting killers. A lab accident causes the building to go into lock-down and the employees are trapped inside with the crazed killers.

Beautiful girls are dying at the hands of a deranged masked killer. Every kill is more brutal than the last. Worst of all, it's happening live on camera.

For hundreds of years, Native American culture has believed in the evil cannibalistic spirit known as "the wendigo". For those who had taken part in cannibalism, no matter the reason, it was aid "the wendigo" would take possession of the person's body and soul. Once the wendigo would take possession of the human host,the host would develop and insatiable desire to eat human flesh. In the deep woods of Northern Pennsylvania, a small town Sheriff (Brian Anthony) is investigating a bloody crime scene. On the scene, he meets Angeni Stonechild (Cheyenne King), a traveling physician treating patients in the area. During the investigation, the two stumble upon dead bodies, a slew of relentless hit men, and two mysterious individuals being protected by federal agents. With a trail of mutilated bodies piling up, the sheriff and Angeni must not only confront the dangerous assassins but also find a way to destroy.....The Wendigo!

A husband and wife, whose marriage is built on shifting sand, find themselves imprisoned by a sadistic killer - forced to make choices that will ultimately determine their family's survival or demise.