In 1912, the notorious and violent prisoner Robert Franklin Stroud is transferred to the Leavenworth Prison convicted for murdering a man. When a guard cancels the visit of his mother, Elizabeth Stroud, due to a violation of the internal rules, he stabs and kills the guard and goes to trial three times. He is sentenced to be executed by the gallows, but his mother appeals to President Woodrow Wilson who commutes his sentence to life imprisonment. However, the warden, Harvey Shoemaker, decides to keep Stroud in solitary for the rest of his life. One day, Stroud finds a sparrow that has fallen from the nest in the yard and he raises the bird until it is strong enough to fly. Stroud finds a motivation for his life raising and caring for birds and becomes an expert in birds. He marries Stella Johnson and together they run a business, providing medicine developed by Stroud. But a few years after, Stroud is transferred to Alcatraz and has to leave his birds behind.

A criminal mastermind has set in motion a plan to infiltrate a high tech prison in order to persuade a death row inmate to reveal the whereabouts of $200 million worth of gold. It's up to an undercover FBI agent to stop him before it's too late.