Spanish director Sebastián, his executive producer Costa and all his crew are in Bolivia, in the Cochabamba area, to shoot a motion picture about Christopher Columbus, his first explorations and the way the Spaniards treated the Indians at the time. Costa has chosen this place because the budget of the film is tight and here he can hire supernumeraries, local actors and extras on the cheap. Things go more or less smoothly until a conflict erupts over the privatization of the water supply. The trouble is that one of the local actors, is a leading activist in the protest movement.

In 1965, Ernesto 'Che' Guevara resigns from his Cuban government posts to secretly make his latest attempt to spread the revolution in Bolivia. After arriving in La Paz, Bolivia late in 1966, by 1967, Che with several Cuban volunteers, have raised a small guerrilla army to take on the militarist Bolivian movement. However, Che must face grim realities about his few troops and supplies, his failing health, and a local population who largely does not share his idealistic aspirations. As the US supported Bolivian army prepares to defeat him, Che and his beleaguered force struggle against the increasingly hopeless odds.