Medical student Paula Henning wins a place at an exclusive Heidelberg medical school. When the body of a young man she met on the train turns up on her dissection table, she begins to investigate the mysterious circumstances surrounding his death, and uncovers a gruesome conspiracy perpetrated by an Antihippocratic secret society operating within the school.

After a tragic car accident where his girlfriend Ryôko Ooyama (Nami Tsukamoto) died, Hiroshi Takagi (Tadanobu Asano) suffers amnesia with his memories completely blanked. When he sees a book about dissection, he decides to join the medical school with the support of his parents. In the dissection class, his group participates of the autopsy of a young woman, and while cutting apart the tissue, he partially recalls his accident. Later, when he sees a tattoo in the arm of the corpse, he discloses that she was his girlfriend and becomes obsessed to go further in the examination of the body.