Charming country bumpkin Duane Bradley takes a motel room in New York with no other luggage then a basket. In a flash back-series we learn it contains his surgically removed Siamese twin who is not only physically deformed so badly the doctors hesitated to consider him a human, but is also the vindictive drive of their trip, with the purpose to kill off all those he blames. But in the reception of one of those doctors, Duane gets his first ever date, with the receptionist, and wants to start a positive life too - when the freak twin escapes, these scene is set for a grim finale.

In Providence, a husband and wife die in a botched robbery; we see flickers of his last memories. His heart goes to Terry Bernard, a single father raising a girl with a rare degenerative disease. After the operation, Terry has flashes of memory from the last moments of the dead donor's life. Then, he recognizes one of the donor's killers and follows him into an alley. Within days, Terry becomes an unwilling avenger, with a police detective on his trail. Meanwhile, he begins a romance with his daughter's doctor, his moods complicated by memory flashes, the donor's deepening presence in both Terry's mind and body, and the unexplained bond among the donor's killers. Can this end well?