In St. John College, the freshmen and best friends Luke and Roger meet the sexy blond cousins Lilly and Constance in the laundry of their building. They are next-door neighbors, and the experienced girls invite the young men to visit them anytime. Lilly forgets a package of coins in the laundry, and Luke goes to their room to return it. The room is empty, and he sneaks around, when the two girls arrive. Luke hides himself in the wardrobe, and through an opening, he sees Lilly with many tentacles on her breast. Luke tries to convince his friends that the girls are aliens, planning to attack Earth, but nobody believes in him. Meanwhile, some friends of them are found dead, with the internal organs completely frozen.

The Planet Express crew must work to fix rips between their universe and another inhabited by a planet-sized, tentacle alien which soon takes over the Earth and uses it's ability to control Fry to command an entire religion which takes over and convinces the inhabitants of Earth to abandon the Earth to live in a pseudo-heaven, leaving the robots of the world to inherit the planet.