When two freshmen pledges are accepted into the biggest party frat on campus (ALPHA HOUSE), they think they have it all. That is, until the assistant dean forces the Alphas to share their house with a sorority or face expulsion from school. Not wanting to see their lifelong dream of becoming Alphas destroyed, the pledges convince the other members of the house to take back what's theirs, waging an epic battle of the sexes to fight for their right to party.

Steve is a man who has it all, a successful career, wonderful children, beautiful home and a loving wife. However, returning to his home after work on his birthday, he finds his house deserted and darkened with almost all the lightbulbs missing, all easy access outside cut off and a videotape waiting for him. Playing that tape, he watches a bizarre and grueling recording in which his wife explains her grievance with him, her reasons for disappearing with the children and her revenge for how he treated her in a way he would never forget.

In Ohio, Priscilla Chase is the VP of a company that works bringing new business to Cleveland. She has been married for more than ten years with Jack Chase, the biology teacher from the local public school. Priscilla is successful in her career but is frigid and has never reached an orgasm, hurting her frustrated husband. When Priscilla decides to buy a vibrator, Jack is seduced by his teenage student Kristen Taylor and recovers his self-esteem, working out, losing weight and dressing adequately. Priscilla has new sexual experiences and becomes closer to Wayne the Pool Guy, the constructor of swimming pools in her neighborhood since she was a child. The new relationships upgrade the personal and professional lives of Priscilla and Jack.