In a world ravaged by disease, he's the only cure... and the last hope for human-kind.

It was an ingenious enough plan: rob the Riviera Casino's count room during an Elvis impersonator convention. But Thomas Murphy decided to keep all the money for himself and shot all his partners, including recently-freed ex-con Michael Zane. With $3.2 million at stake, the Marshals Service closing in, and single mom Cybil Waingrow and her son Jesse constantly confounding things, Michael must track down Murphy.

When Eastern European criminals Oleg and Emil come to New York City to pick up their share of a heist score, Oleg steals a video camera and starts filming their activities, both legal and illegal. When they learn how the American media circus can make a remorseless killer look like the victim and make them rich, they target media-savvy NYPD Homicide Detective Eddie Flemming and media-naive FDNY Fire Marshal Jordy Warsaw, the cops investigating their murder and torching of their former criminal partner, filming everything to sell to the local tabloid TV show "Top Story."

In the year 3028 A.D., Earth is being attacked by the Drej, which are aliens made of pure energy! The Drej mother-ship destroys Earth with an energy beam just as hundreds of space vehicles manage to escape with the last of mankind aboard! One of the escapees is Sam's young son Cale, who carries with him a ring given to him by his father. Fifteen years later, Cale works on a salvage station, eking out a rough life and hating his father for having disappeared aboard the Titan so long ago. Without a home planet, surviving humans have been reduced to outer space drifters and are constantly bullied and looked down on by other space-faring races. A human captain named Joseph Korso and his pilot Akima seek out Cale and explain that he must help them find the Titan which contains a mechanism that will create a new Earth and therefore unite all of humanity. Meanwhile, the Drej wants to find the Titan so that they can destroy it...