On Halloween in 1963, Michael Myers murdered his sister, Judith. In 1978, he broke out to kill his other sister, Laurie Strode. He killed all of her friends, but she escaped. A few years later, she faked her death so he couldn't find her. But now, in 1998, Michael has returned and found all the papers he needs to find her. He tracks her down to a private school where she has gone under a new name with her son, John. And now, Laurie must do what she should have done a long time ago and finally decided to hunt down the evil one last time.

Six college students take a wrong turn and find themselves lost in a strangely deserted rural town... only to discover that this deceptively quiet place hides a murderous cult of children controlled by evil forces! Yet even as bodies begin cropping up all around them, the young friends decide to stay and rescue the children... or die trying!

Chucky hooks up with another murderous doll, the bridal gown-clad Tiffany, for a Route 66 murder spree with their unwitting hosts, two eloping high-school graduates.