Wild. Untamed. Legendary. Buffalo Girls celebrates the bold escapades of tough-talking Calamity Jane Canary and her illustrious cohorts. It's the waning days of the Wild West and Jane, the rough 'n' rugged cowgirl, is searching not only for her long-lost daughter, but the Wild West she once knew. Jane traverses plains, mountains and continents until she finally discovers the answer to her problems: Dora, the vivacious, gold-hearted madam who's been her one true friend all along.

After another hard night at McCool's, bartender Randy runs into Jewel. The seductive lady seems to have evaded a rape pretty closely, and when the man comes back, she puts a bullet in his head. After all these events (and others), Randy takes Jewel home, and the two become a couple. Yet Jewel begins to develop into a very demanding girlfriend and drives Randy into committing crimes for her and her elaborate lifestyle. Randy's cousin Carl is driven crazy by Randy's incredibly sexy girl as well as the investigating officer, Detective Dehling.