Set against the backdrop of the Nashville music scene, the new drama revolves around a 40-year-old superstar Rayna Jaymes, whose star begins fading. She is forced to team up with Juliette Barnes on tour in order to maintain her label's support for her latest record, whose sales have been underwhelming.

When the bad boy John inherits an isolated house in an island, he invites his brother and student of veterinary Matt and his girlfriend Nikki together with their common friends Sara and Noah to fly with him in his hydroplane and spend a couple of days having good time in the place. Later Sara is attacked by a dog and they recall that in the other side of the island there was a facility for training dogs that had been shutdown to avoid a rabies outbreak. While walking through the woods, they find a man called Luke, who sailed with his girlfriend Jenny to the island, covered of blood and Luke is killed by a pack of hounds. The group runs to the house and the animals put the place under siege, and they try to find a means of escape. When the survivors reach the compound, they disclose that the dogs have been genetically redesigned to become a breed of killers.

In the 70's, the boy Billy is born with yellow skin due to a lever disease and his dysfunctional mother rejects him. Later he witnesses his mother and her lover killing his beloved father and burying him in the basement of their house, and he is locked in the attic alone along his childhood. When he is a teenager, he is sexually abused by his mother and she has a baby girl called Agnes. During Christmas, the deranged Billy escapes from his imprisonment, kills his mother and stepfather and blinds one eye of Agnes. He is declared insane and his sister is sent to an orphanage. In the present days, Billy escapes from the Clark Sanatorium to spend Christmas with his family. Meanwhile, his former house is the Delta Alpha Kappa sorority house in the campus of the Clement University, and the housemother and the sisters Kelli Presley, Dana, Lauren Hannon, Megan, Heather, Megan Helms, Melissa...