The provocative tale of a woman (Marianna Palka) who snaps under crushing life pressures and assumes the psyche of a vicious dog. Her philandering, absentee husband (Jason Ritter) is forced to become reacquainted with his four children and sister-in-law (Jaime King) as they attempt to keep the family together during this bizarre crisis.

Riley searches for a cure to the virus that took over Samantha before it consumes him and the entire world.

They're in their 20s. He works in a video store; he's eager, chatty, sleeps in his car. She rents adult films, looks disheveled, rarely speaks. He chats her up, she brushes him off. He takes her address from store records and contrives to run into her. He rings her doorbell; she tells him to go away. He invents a story of a great-aunt who's died; she lets him in but holds a butcher knife between them. So it goes. He presses for a relationship; she ignores him, insults him, or yells. He's persistent, inviting her out, cooking, washing her hair. Both have demons and, as their natures become more clear, his addictive personality and her sex nausea may be on a collision course.