Something's wrong at the Rileys. Married nearly 30 years, Doug and Lois rarely talk. She doesn't leave their Indianapolis home, and she's ordered a gravestone with their names and birth years on it. He has a long-time Thursday night mistress whom he invites to go with him to a plumbing supply conference in New Orleans. Once there, Doug calls Lois to say he's staying for a while. What's he leaving behind and what's he looking for in New Orleans? And Lois, can she break out?

Virginia small town local Ford Sawyer, a comics artist, takes an instant liking to his new neighbor, Cilla McGowan, a former child TV starlet who moves from L.A. to renovate her Hollywood celebrity grandmother Janet's rural last residence and start a career after passing the local contractors exam. Grumpy old neighbor Carl Hennessy is suspected of the vandalism on her garden, garage and home, even knocking friendly ex Steve Chensky. Seeking comfort and security, Cilla comes to depend on Ford, who elected her as model for his next hammer-swinging Celtic comic heroin, and they fall in love. Janet's stuff yields intriguing information which proves relevant for the present aggression, with unexpected ramifications.

A group of talented but rebellious 'rock-star scientists' find themselves in a race against time to save Earth when a comet makes an unexpected turn towards our blue planet where all life may cease to exist within days if our small town heroes fail to find a solution.

A doctor devotes his life's work to finding a cure for breast cancer.