In Manhattan, when a client is bitten by a rat in the dressing room of the Garsons Department Store and contracts Weil's disease, the manager Susan Costello is assigned to hire and give all the necessary support to the best exterminator in New York, Jack Carver. The efficient Jack and his assistant Ty find a colony of mutant rats and try to convince the health department administrator and former partner of Jack, Ray Jarrett, how serious the infestation is. But the politician Ray is interested in covering the problem to protect economical interests of powerful groups.

In New York, the competent creative director of Birk Advertising Eddie Shneider is living a successful moment of his professional life and is engaged and has just proposed Judy Birk, the daughter of the owner of the company where he works. Eddie is also a wolf and very successful with many women, and is having an affair with a neighbor of the street where he lives with Judy. When he gets the account of the greatest American airline for his company, he is promoted to partner and he celebrates with his assistant and friend Angelina Sable in a lunch party in a restaurant. After hours, when they are in the garage, Angeline notes that she had forgotten her car keys in the office, and when she returns, she is violently raped by the despicable brother of Judy, Anthony Birk. On the next morning, when Eddie arrives in the garage, he finds the traumatized Angeline on the floor and he takes her to a hospital...