Ambrose McKinley, a cantankerous blind vet, moves into a retirement community only to learn the residents there have been dying, not from old age, but from dog attacks. After surviving his own encounter with a canine one night, Ambrose comes to believe the assailants are much more than mere dogs...

Cullen Bohannon, a former soldier and slaveholder, follows the track of a band of Union soldiers, the killers of his wife. This brings him to the middle of one of the biggest projects in US history, the building of the transcontinental railroad. After the war years in the 1860s, this undertaking connected the prospering east with the still wild west.

The four sons (Diesel, Green, Pepper, Davoli) of major Brooklyn mobsters have to team up to retrieve a bag of cash in a small Montana town ruled by a corrupt sheriff. Specifically, the story gets started when Matt Demaret (Pepper) goes on a job to deliver the money for his mob father (Hopper) on the advice of his uncle (Malkovich). Things don't go as planned though...

In the 1980s, college student Samantha Hughes takes a strange babysitting job that coincides with a full lunar eclipse. She slowly realizes her clients harbor a terrifying secret; they plan to use her in a satanic ritual.

Will Graham is a former FBI agent who recently retired to Florida with his wife Molly and their young son. Graham was a 'profiler'; one who profiles criminal's behavior and tries to put his mind into the minds of criminals to examine their thoughts while visiting crime scenes. Will is called out of his self-imposed retirement at the request of his former boss Jack Crawford to help the FBI catch an elusive serial killer, known to the press as the 'Tooth Fairy', who randomly kills whole families in their houses during nights of the full moon and leaves bite marks on his victims. To try to search for clues to get into the mind of the killer, Will has occasional meetings with Dr. Hannibal Lecktor, a charismatic but very dangerous imprisoned serial killer that Will captured years earlier which nearly drove him insane from the horrific encounter that nearly cost Will's life...

In Rochester, a pre-teen girl is abducted, raped, and murdered. Detective Megan Paige investigates: she works long hours obsessively, and soon she's seeing visions of the dead girl. The FBI profiles the killer as a spontaneous drifter, lucky not to get caught; Megan thinks he's local and a methodical planner. She notes that the victim's first and last names and the place the body was left start with "C." When a second murder follows the same pattern, Megan is vindicated, but her obsessions get the best of her, and her mental state impedes her work. With the help of medication, therapy, and a friend, can she regain her equilibrium and catch the alphabet killer?

In the 1860s, five men have been tracking a sixth across Nevada for more than two weeks. They shoot and wound him, but he gets away. They pursue, led by the dour Carver, who will pay them each $1 a day once he's captured. The hunted is Gideon, resourceful, skilled with a knife. Gideon's flight and Carver's hunt require horses, water, and bullets. The course takes them past lone settlers, a wagon train, a rail crew, settlements, and an Indian philosopher. What is the reason for the hunt; what connects Gideon and Carver? What happened at Seraphim Falls?