In You, Me and Him we meet lesbian couple Olivia and Alex (Lucy Punch, Faye Marsay) who, despite their age difference, are very much in love. But as the question of pregnancy rears its head and their neighbour John (David Tennant) befriends them, they both start making some truly disastrous decisions.

Southall Police are baffled by four successive homicides of East Indians, and request Detective Raj Murthy to mingle with the local community and find out who is behind the murders. Raj does so and meets with his childhood girlfriend, Roopi Sethi, who lives with her widowed mother and brother, Jazz. Both continue to meet and an unsuspecting Raj will be taken by surprise when his superiors consider Roopi as a suspect in these homicides as she knew all the deceased victims. Before they could take any further steps, a fifth homicide occurs - that of Mrs. Goldstein. Again this victim is also known to Roopi, but in order to arrest her, they must find evidence and also a motive.

A prison ship on its way to a remote island prison runs aground on rocks and sinks. Mixed survivors of cons and prison guards struggle ashore, only to discover to their horror that another survivor has made it ashore before them. Murderous psychotic, Leo Rook, who not only had a hand in the ship's sinking but has decapitated all but one of the island's lighthouse crew. Stranded, with no means of escape or call for help, the survivors must face a night of terror as they know that since they've learned that Leo survived going down with the ship he can't let any of them live and is hellbent on adding their severed heads to his collection.

A comet hits Ireland, and a bigger one is on its way towards the U.S. where 900 million people have to be evacuated.