When a new family moves to an old house in Amityville, they are tormented and tortured by an evil spirit living in the home while trapped by the malicious townspeople who want to keep them there.

After inheriting the family mortuary, a pyrophobic mortician accidentally exposes hundreds of un-cremated bodies to toxic medical waste. As the corpses re-animate, the mortician's inheritance-seeking younger brother unexpectantly shows up, stumbling upon a full zombie outbreak!

An offshore drilling accident releases a giant primordial shark. When the shark flies and walks on land threatening to turn a bikini contest into a bloodbath, marine biologist Kat Carmichael arrives to destroy the shark and save beach-goers. Her efforts are stymied by corporate bad guy Roger Wade and his flunky Stewart who are only interested in their own agenda of money, money, money. With time running out for beach loving humans, Carmichael recruits heroic skipper Chuck and fearless disc jockey Dynamite Stevens to help her blast the blood thirsty shark back to a watery grave.

After a plane crash where a boy is the only survival, the famous anchor Erika Lawson convinces her husband and cameraman Scott to adopt the child. They bring Donald home and Scott's father Big Jake offers to take care of him while the couple works. However, after a series of bizarre accidents that culminates with the death of Jake, the nanny Lucy Fir comes to the Lawson's home to work. However, Lucy is actually a follower of the Anti-Christ and together with Donald, they bring more tragedies to the Lawson's family.

In Louisiana, the thirty-five year old single mother Lavina delivers a baby boy and a monster in the evil Whateley House. Ten years later, Dr. Henry Armitage and his assistant Professor Fay Morgan discover that the page 751 of every copy of the Necronomicon is missing and The Black Brotherhood has summoned the gate keeper Yog Sothoth to leave the portal opened to the demons and ancient gods. They invite the arrogant and skeptical Professor Walter Rice that can translate the Necronomicon to help them to seek the book. Meanwhile Lavina's son Wilbur Whateley ages very fast and seeks the missing page to open the portal.

Handsome, romantic, sexy gentile Charlie enjoys his honeymoon with liberal-Jewish marriage counselor Ava. It's cut short when her parents Bradley and Betty, who always seemed the perfect couple, suddenly border on divorce over an old affair and poorly matched expectations. Worse, in turn they invite themselves to move in and drive the newly-weds crazy. Ethics prevent Ava from taking them on as clients and the colleagues she refers to prove hopelessly inept. Meanwhile Charlie's impulsive buddy Gerber, the eternal bachelor party animal, has married Polish green-card-chaser Kasia.

In this epic disaster film of faith, a mother and father search for their only child as a giant asteroid headed for Earth triggers a series of apocalyptic events.