The physician's death orphans his two adolescent daughters. Their older brother is able to convert some of the doctor's small estate to cash. But it is late in the day, and with the banks closed he stores the money in his father's household safe. The slatternly housekeeper, aware of the money, enlists a criminal acquaintance to crack the safe. She attempts to get into the adjacent room where the sisters tremble in fear, but finds that the door is locked. The drunken housekeeper menaces them by brandishing a gun through a hole in the wall. But the resourceful girls use the telephone to call their brother who has returned to town. He gets the message and organizes a rescue party.

A potentially violent patient in an insane asylum is calmed when he hears a nurse playing the piano. But shortly afterwards he breaks free, eludes his pursuers, and acquires a gun. He soon comes to a house where a young wife is home alone, and there is a tense confrontation.

Susie, a plain young country girl, secretly loves a neighbor boy, William. She believes in him and sacrifices much of her own happiness to promote his own ambitions, all without his knowledge. Eventually he rises to a position of success and sophistication, and Susie realizes that she has through her own efforts raised him to a level where he is inaccessible to her.

The callous rich, portrayed by Lennox, think only of their own pleasure. Anna is but a poor country girl whom Lennox tricks into a fake wedding. She believes that it is true, but secret, while he has his way with her. When she is pregnant, he leaves her and she must have the baby, named Trust Lennox, on her own. When the baby dies she wanders until she gets a job with Squire Bartlett. David falls for her, but she rejects him due to her past and then Lennox shows up lusting for Kate. Seeing Anna, he tries to get her to leave, but she doesn't, and she tells no one about his past. When Squire Bartlett learns of her past from Martha, the town gossip, he tosses Anna out in a snow storm. But before she goes, she fingers the respected Lennox, as the father of her dead baby and the spoiler of herself.

A young couple struggle to get ahead, the wife always assuaging the troubles of her melancholy husband. As he climbs the ladder of success, he abandons the homely values and takes up with another woman. His wife leaves him, returning to her mother's home where she bears a child. When the husband is abandoned by his concubine, remorse drives him to find his wife...

John Howard Payne leaves home and begins a career in the theater. Despite encouragement from his mother and his sweetheart, Payne begins to lead a life of dissolute habits, and this soon leads to ruin and misery. In deep despair, he thinks of better days, and writes a song that later provides inspiration to several others in their own times of need.

Cheng Huan is a missionary whose goal is to bring the teachings of peace by Buddha to the civilized Anglo-Saxons. Upon landing in England, he is quickly disillusioned by the intolerance and apathy of the country. He becomes a storekeeper of a small shop. Out his window, he sees the young Lucy Burrows. She is regularly beaten by her prizefighter father, underfed and wears ragged clothes. Even in this deplorable condition, Cheng can see that she is a priceless beauty and he falls in love with her from afar. On the day that she passes out in front of his store, he takes her in and cares for her. With nothing but love in his heart, he dresses her in silks and provides food for her. Still weak, she stays in his shop that night and all that Cheng does is watch over her. The peace and happiness that he sees last only until Battling Burrows finds out that his daughter is with a foreigner.

When Mrs. Harding dies, she leaves a mysterious letter to her pastor. The note tells how her cold, miserly husband worked her to death. She asks the pastor to administer a small trust which she has bequeathed her daughter so that the girl might enjoy some finery which her father has always denied her. The village milliner carries the latest hat styles from New York, one of which has caught the girl's fancy. The pastor, loyal to the dying mother's wishes, buys the young lady the hat. Soon gossip spreads through the village...

Two brothers, Phil and Ted Stoneman, visit their friends in Piedmont, South Carolina: the family Cameron. This friendship is affected by the Civil War, as the Stonemans and the Camerons must join up opposite armies. The consequences of the War in their lives are shown in connection to major historical events, like the development of the Civil War itself, Lincoln's assassination, and the birth of the Ku Klux Klan.

Beautiful half-breed Pearl Chavez becomes the ward of her dead father's first love and finds herself torn between her sons, one good and the other bad.