A man is released from prison after serving a long time for killing a man who tried to kill his best friend. Once out, he just wants to live a normal life, but his best friend immediately gets him into a new heap of serious troubles.

Ray Bradstone (Levesque) is the best wheel man in the business, but he is determined to go straight and be the best parent he can be to his daughter, Sally (Winter), and make amends with his ex-wife, Lynne (Gish). As Ray struggles to find honest work, his old bank-robbing crew, led by Phillip Larue (Corrigan), offers him one last job. He agrees at first, but changes his mind at the last second leaving the crew without a driver. Ray decides instead to serve as a chaperone for Sally's school field trip. When the robbery goes awry, Larue blames Ray and chases the school bus all the way to the Museum of Natural History in New Orleans. Ray must deal with Larue, while supervising Sally's class on what becomes one of the craziest school trips ever.

Blade finds himself alone surrounded by enemies, fighting an up hill battle with the vampire nation and now humans. He joins forces with a group of vampire hunters whom call themselves the Nightstalkers. The vampire nation awakens the king of vampires Dracula from his slumber with intentions of using his primitive blood to become day-walkers. On the other side is Blade and his team manifesting a virus that could wipe out the vampire race once and for all. In the end the two sides will collide and only one will come out victorious, a battle between the ultimate vampire whom never knew defeat, facing off against the greatest vampire slayer.