The hero of an unlikely airplane disaster must overcome his own inadequacies, improbable accidents and his former girlfriend in order to save a space shuttle from destruction in this spoof sequel of the disaster parody Airplane!

Professional photographer L.B. "Jeff" Jeffries breaks his leg while getting an action shot at an auto race. Confined to his New York apartment, he spends his time looking out of the rear window observing the neighbors. He begins to suspect that a man across the courtyard may have murdered his wife. Jeff enlists the help of his high society fashion-consultant girlfriend Lisa Freemont and his visiting nurse Stella to investigate.