In the slum in Morro da Sinuca, a couple of days before turning eighteen year-old, Laranjinha tells his best friend and also orphan Acerola that he misses his unknown father. Acerola decides to help his needy friend to find his father and they discover that he is in prison convicted for killing a man during a robbery and near to be released on parole. Meanwhile, Acerola's wife and babysitter Cris is invited to work in São Paulo and she sees the chance to raise money to buy a house of her own; she tells Acerola that he must take care of their son Clayton alone for one year. When the owner of the hill and Laranjinha's cousin Madrugadão is betrayed by his right-hand Nefasto, he is expelled from the slum and Laranjinha and Acerola have also to leave the hill. While Madrugadão plots a plan to invade and recover the hill with the support of the gang of the drug lord from Morro do Careca, Acerola and Laranjinha unravel the past of their fathers.

A city is ravaged by an epidemic of instant "white blindness". Those first afflicted are quarantined by the authorities in an abandoned mental hospital where the newly created "society of the blind" quickly breaks down. Criminals and the physically powerful prey upon the weak, hoarding the meager food rations and committing horrific acts. There is however one eyewitness to the nightmare. A woman whose sight is unaffected by the plague follows her afflicted husband to quarantine. There, keeping her sight a secret, she guides seven strangers who have become, in essence, a family. She leads them out of quarantine and onto the ravaged streets of the city, which has seen all vestiges of civilization crumble.