In a small town south of San Francisco, Sheriff Paul Del Moral (Pepe Serna) is driving home through the fog when he accidentally strikes a pedestrian, a lone Japanese man. However, before an investigation can take place the man disappears from the hospital without a trace. At the same time, Japanese mystery author Aki Akahori (Ayako Fujitani) takes a trip to San Francisco in order to escape the press tour for her latest book--a potboiler in her world famous "Inspector Takabe" series. Feeling lonely and vulnerable, she begins a romantic affair with a mysterious Japanese traveler from Reno (Kazuki Kitamura). Her new lover is charismatic and charming but abruptly disappears from the hotel, leaving behind his suitcase and a trail of questions...

After having been rewarded for solving the mystery of the Pink Panther Diamond, inspector Jacques Clouseau has been assigned to minor tasks by his boss inspector Dreyfus so as not to have him in his way anymore. Unfortunately, the famous diamond has once again been stolen as have many other artifacts in a series of burglaries around the world. His past success will enable inspector Clouseau to be part of the dream team comprised of the greatest detectives of the affected countries, where he will be able to display his numerous talents across the world.