Professor Sherman Klump is getting married. And the Klump family could not be more delighted for him. But Buddy Love, his Mr. Hyde alter-ego from the first film, is back and trying to make it on his own. Buddy keeps resurfacing in untimely outbursts, and threatening the portly professor's marriage plans to colleague Denise Gaines. Utilizing Denise's cutting-edge DNA research, Sherman decides to rid himself of his monstrous nemesis -and his disruptive outbursts-once and for all by extracting...

Ryan Harrison, a violin god, superstar and sex symbol does not want to cheat on sexy Lauren Goodhue's husband with her. Shortly after that Mr. Goodhue is found murdered and Ryan suddenly finds himself being the main suspect. After being sentenced to death he manages to flee while being transferred to his execution site. Now, all the world is after him as he stumbles from one unfortunate incident to the next in order to find the real murderer.