A gangster, a crooked banker, a hitman and an arab terrorist are stranded and on the run in a small village in South America. Their only chance of escape is to drive two trucks filled with unstable nitroglycerin up a long and rocky mountain road in order to plug an escalating oil refinery blaze. With their deadly cargo likely to explode at the slightest bump, the four men must put aside their differences and work together to survive.

In present day Montreal, a famous Nicolo Bussotti violin, known as "the red violin," is being auctioned off. During the auction, we flash back to the creation of the violin in 17th century Italy, and follow the violin as it makes its way through an 18th century Austrian monastery, a violinist in 19th century Oxford, China during the Cultural Revolution, and back to Montreal, where a collector tries to establish the identity and the secrets of "the red violin."