The feared bandit Cobra Verde ( ) is hired by a plantation owner to supervise his slaves. After the owner suspects Cobra Verde of consorting with his young daughters, the owner wishes him gone. Rather than kill him,the owner sends Cobra Verde to Africa. The only white man in the area, Cobra Verde finds himself the victim of torture and humiliation. Later, he trains soldiers in a rebel army. Far from home, Cobra Verde is on the edge of madness.

A few decades after the destruction of the Inca empire, a Spanish expedition leaves the mountains of Peru and goes down the Amazon river in search of gold and wealth. Soon, they come across great difficulties and Don Aguirres, a ruthless man who cares only about riches, becomes their leader. But will his quest lead them to "the golden city", or to certain destruction?