A zombie is found aboard a boat off the New York coast which belongs to a famous scientist. Peter West, a journalist, travels to the Antilles with Ann, the daughter of the scientist. On the way, they meet with Brian, an ethnologist, and Susan. When they arrive at Matul Island, they find Dr. Menard, and discover a terrifying disease which is turning the islanders into horrifying zombies which devour human flesh and seem indestructible..

Angela deMarco is unhappily married to high Mafia member Frank deMarco. When Frank is killed, Angela takes the opportunity to break free of the Mafia world entirely and start a new life. But Frank's boss, Tony Russo, begins to court the unresponsive Angela. The FBI begins surveillance on her, thinking her to be his new mistress. FBI agent Mike Downey goes undercover as Angela's neighbor, but soon finds himself attracted to Angela himself.