Andrew Largeman is a semi-successful television actor who plays a retarded quarterback. His somewhat controlling and psychiatrist father has led Andrew ("Large") to believe that his mother's wheelchair bound life was his fault. Andrew decides to lay off the drugs that his father and his doctor made him believe that he needed, and began to see life for what it is. He began to feel the pain he had longed for, and began to have a genuine relationship with a girl who had some problems of her own.

Husband, wife, and daughter have moved from Boston to Williamstown. At 16, Samantha treats her mother shabbily, but when the two of them are in a horrific car crash, the mother wills Sam to live, somehow losing her own life while her spirit enters Sam. Can she convince husband Ben that she's his wife inside his daughter's body, what if he believes her, and can she live Samantha's life (discovering all her daughter's secrets) while she figures out what to do? What's Ben's part in this secret life?