Hapless satirical songwriter Henry Phillips is lured to LA by renowned TV producer Jay Warren, who wants to make a show about the life of a struggling performer. When Jay sees Henry bomb at a local club, he is convinced that this story must be told. With the support of his longtime musician friend Jillian, and his well-meaning but sub-par manager Ellen Pinsky, Henry endures the ups and downs of LA living, and even secures what appears to be the Hollywood dream. But as a major TV network gets involved, he must decide whether his legacy will be to make jokes, or become the butt of them.

"Muffin Top: A Love Story" is the story of Suzanne (Cathryn Michon) a Women's Studies Pop Culture professor at Malibu University, who studies images of women in the media for a living, and yet is made insecure by the constant parade of female perfection that is our airbrushed culture. She has been going through IVF treatments to get pregnant by her network executive husband (Diedrich Bader), but discovers on her birthday, that her husband has knocked up his younger, skinnier, co-worker (Haylie Duff) and wants a divorce. Happy Birthday! She goes on to find a more authentic version of who she really is, despite the delights of being suddenly single in Los Angeles, where low self-esteem for women is our number one export to the world.

The clumsy and shy Stanley is a nice fellow, beloved by his colleagues in the office. He has a crush on the gorgeous new-hire Diana, but he has difficulties to get close to her. When Stanley finally invites Diana for a date, he hits the homeless Phil with his Taurus and his planned night turns upside down.

Carl becomes so obsessed with his fear of a terrorist nuclear attack on Los Angeles that he destroys his marriage.