For most of his life, Ignacio Carrillo traveled the villages of northern Colombia, playing traditional songs on his accordion, a legendary instrument said to have once belonged to the devil. He eventually married and settled in a small town, leaving the nomadic life behind. But after the traumatic death of his wife, he vows to never play the accursed accordion again, and embarks on one last journey to return the instrument to its rightful owner. On the way, Ignacio is followed by Fermín, a spirited teenager determined to become his apprentice. Tired of loneliness, Ignacio accepts the young man as his pupil and together they traverse the vast Colombian terrain, discovering the musical diversity of Caribbean culture. Hardened by a life of solitude, Ignacio tries to discourage Fermín from following in his footsteps, but destiny has different plans for them.

Bruno Stroszek is released from prison and warned to stop drinking. He has few skills and fewer expectations: with a glockenspiel and an accordion, he ekes out a living as a street musician. He befriends Eva, a prostitute down on her luck. After they are harried and beaten by the thugs who have been Eva's pimps, they join Bruno's neighbor, Scheitz, an elderly eccentric, when he leaves Germany to live in Wisconsin. In that winter bound, barren prairie, Bruno works as a mechanic, Eva as a waitress. They buy a trailer. Then, bills mount, the bank threatens to repossess the trailer, Eva wants privacy, and inexorably, the promise of a new life deserts Bruno.

From dawn to dusk, a few hours in the life of Monsieur Oscar, a shadowy character who journeys from one life to the next. He is, in turn, captain of industry, assassin, beggar, monster, family man...