Frankenstein, a young medical students, trying to create the perfect human being, instead creates a misshapen monster. Made ill by what he has done, Frankenstein is comforted by his fiancée but on his wedding night he is visited by the monster. A fight ensues but the monster, seeing himself in a mirror, is horrified and runs away. He later returns, entering the new bride's room, and finds her alone.

Edward Elric, the Fullmetal Alchemist, is on the other side of the gate. He has befriended someone who resembles his brother, Al, and has met a gypsy resembling Rose. He finds out that the Germans are planning on opening the gate, and attack the other side, which is Ed and Al's home. Although Al has learned a lot, he cannot stop all of them, and Ed cannot use Alchemy while in the other side. Ed tries to stop them, and Al just tries to be able to talk to his brother again, who everyone else thinks is gone.