Based on the true life experiences of poet Jimmy Santiago Baca, the film focuses on half-brothers Paco and Cruz, and their bi-racial cousin Miklo. It opens in 1972, as the three are members of an East L.A. gang known as the "Vatos Locos", and the story focuses on how a violent crime and the influence of narcotics alter their lives. Miklo is incarcerated and sent to San Quentin, where he makes a "home" for himself. Cruz becomes an exceptional artist, but a heroin addiction overcomes him with tragic results. Paco becomes a cop and an enemy to his "carnal", Miklo.

Santiago's father, Hernan Munez, smuggled his penniless Mexican family over the US border to seek a better, albeit modest future in L.A. Eldest son Santiago dreams of more, like native Angelinos, then joining Hernan's gardening firm. His change arrives when a British ex-pro spots him as an exceptional soccer natural and promises he can arrange a real British talent scout to check him out. Although that falls trough and dad forbids it, Santiago accepts grandma's savings to try out with English premier league club Newcastle. Despite his asthma, he gets in and befriends the freshly transferred, desperately undisciplined bad boy star scorer, party animal Gavin Harris, who becomes his bothersome house-mate, a recipe for trouble and yet each's salvation.