After his best friend dies in a racing accident, biking star Joe agrees to go back on the wheels for an exhibition in Chile. On a test run with his girlfriend Stephanie, they stumble upon a badly injured man dying from a mysterious virus. That's the start of a very bad day for them as they become the target of relentless killers ready to do anything to keep their secret to go out of the mountains.

After an earthquake erupts in Chile, tourist discover that a neighboring prison in the area collapsed in the event, and all surviving criminals managed to break free. Soon they learn that the most terrifying thing, more threatening that Mother Nature, is what she created.

Alicia arrives in South America to vacation with her cousin, Sarah. When Sarah is suddenly called away, Alicia is stuck on a remote island off Chile with three of Sarah's friends, including Brink, an American exchange student with a sadistic streak. Bewildered, frightened, and unable to sleep, Alicia's reality becomes a nightmare from which there is no waking. Ancient indigenous rites, disturbing animal behavior, and captivating hypnotic trances come together in an intense exploration into the darkest corners... when the games go too far, reality unravels with astonishing and deadly consequences.

Jamie (Cera) is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman -- a radical spirit named Crystal Fairy (Hoffmann) -- to come along. What is meant to be a devil-may-care journey becomes a battle of wills as Jamie finds himself locking horns with his new traveling companion. But on a remote, pristine beach at the edge of the desert, the magic brew is finally imbibed, and the true adventure begins.

Naomi Klein gives a lecture tracing the confluence of ideas about modifying behavior using shock therapy and other sensory deprivation and modifying national economics using the "shock treatment" of Milton Friedman and the Chicago School. She moves chronologically: Pinochet's Chile, Argentina and its junta, Yeltsin's Russia, Bush and Bremer's Iraq. A trumped-up villain provides distraction or rationalization: Marxism, the Falklands, nuclear weapons, terrorists; and, always, there is a great shift of money and power from the many to the few. News footage, a narrator, and talking heads back up Klein's analysis. She concludes on a note of hope.