Chucky hooks up with another murderous doll, the bridal gown-clad Tiffany, for a Route 66 murder spree with their unwitting hosts, two eloping high-school graduates.

It's been eight years since the events in the second film, we now see that Andy is a teenager who has been enrolled in a military school. Play Pals Toy Company decides to re-release its Good Guys line, feeling that after all this time, the bad publicity has died down. As they re-used old materials, the spirit of Charles Lee Ray once again comes to life. In his search for Andy, Chucky falls into the hands of a younger boy, and he realizes that it may be easier to transfer his soul into this unsuspecting child. Andy is the only one who knows what Chucky is up to, and it's now up to him to put a stop to it.

The killer doll is back! Glen, the orphan doll offspring of the irrepressible devilish-doll-come-to-life Chucky and his equally twisted bride Tiffany. When production starts on a movie detailing the urban legend of his parents' lethal exploits, Glen heads for Hollywood where he brings his bloodthirsty parents back from the dead. The family dynamics are far from perfect as Chucky and Tiffany go Hollywood and get rolling on a new spree of murderous mayhem; much to gentle Glen's horror. Chucky can't believe that his child doesn't want to walk in his murdering footsteps, and star-struck Tiffany can't believe that the movie will star her favorite actress, Jennifer Tilly, who soon becomes an unwitting hostess to this new family in more ways than one...

When Charles Lee Ray needs to get quick escape from cop, Mike Norris, he takes his soul and buries it into playful, seemingly good guy doll Chucky. Little does he know a little boy by the name of Andy Barclay will be the new owner of him soon-to-come. Charles confides in Andy while he commits numerous murders. Once the adults catch up to Andy's story as truth, it's too late.