Jigsaw and his young apprentice, Amanda, are dead. But the grisly games continue. 5 supposed strangers find themselves in the midst of the big game, and believe they are in a survival of the fittest competition. Via his now infamous video linked doll, Jigsaw conveys the message that they should ignore there instincts, and ignore his advice at their peril. Meanwhile, agent Strahm wants to prove that Hoffman is an apprentice to Jigsaw, and pursues him as he continues his twisted games. What Strahm does not realize is that Hoffman is testing him all along, and must pass his test in order to stay alive.

Special Agent Strahm is dead, and Detective Hoffman has emerged as the unchallenged successor to Jigsaw's legacy. However, when the FBI draws closer to Hoffman, he is forced to set a game into motion, and Jigsaw's grand scheme is finally understood.