Pandemic is set in the near future, where a virus of epic proportions has overtaken the planet. There are more infected than uninfected, and humanity is losing its grip on survival. Its only hope is finding a cure and keeping the infected contained. Lauren (Rachel Nichols) is a doctor, who, after the fall of New York, comes to Los Angeles to lead a team to hunt for and rescue uninfected survivors.

In a world devastated by an outbreak, Brian, his girlfriend Bobby, his brother Danny and their friend, Kate, are heading to a beach where the brothers spent their childhood vacations expecting it to be a sanctuary. When their car breaks down on the road in the desert, they negotiate with a man called Frank, who is also stranded but without gas. He is trying to get his daughter Jodie to the hospital (she is infected with a disease of some kind), they all decide to travel together. During the journey, massive moral dilemmas arise, as events head into a downward spiral.