Joe Pendleton is a football quarterback preparing to lead his team to the Superbowl when he is almost killed in an accident. An overanxious angel plucks him to heaven only to discover that he was not ready to die, and that his body has been cremated. Another body must be found without his death being discovered, and that of a recently murdered millionaire is chosen. His wife and accountant, the murderers, are confused by this development, as he buys the Los Angeles Rams in order to once again quarterback them into the Superbowl. At the same time, he falls in love with an English environmental activist who disapproves of his policies and actions.

Andrew Largeman is a semi-successful television actor who plays a retarded quarterback. His somewhat controlling and psychiatrist father has led Andrew ("Large") to believe that his mother's wheelchair bound life was his fault. Andrew decides to lay off the drugs that his father and his doctor made him believe that he needed, and began to see life for what it is. He began to feel the pain he had longed for, and began to have a genuine relationship with a girl who had some problems of her own.

A sadistic warden asks a former pro quarterback, now serving time in his prison, to put together a team of inmates to take on (and get pummeled by) the guards.