Biker Cary Ford is framed by an old rival and biker gang leader for the murder of another gang member who happens to be the brother of Trey (Ice Cube), leader of the most feared biker gang in the country. Ford is now on the run trying to clear his name from the murder with Trey and his gang looking for his blood.

Just out of prison, Nate needs to regain his family's trust and takes them on a road trip. His plans take a turn for the worst when a group of criminals covertly stash four million dollars from a deadly bank heist in his car; with the aim of collecting it once through a police roadblock up ahead. Nate's family complete their unknown task and speed off down the highway; but the criminals need their money, and will stop at nothing to reclaim it.

When plans for a weekend vacation hit a dead end, a group of close-knit friends find themselves stranded in unfamiliar territory, pursued by a menacing, blood thirsty predator. Holed up in an isolated cabin, tensions mount as long-buried secrets are revealed. As the body count rises, the group must put their differences aside and fight for survival.