With aerial footage from 54 countries, Home is a depiction of how the Earth's problems are all interlinked.

In London, the radiologist Gina McVey organizes a surprise birthday party to her father John McVey with her boyfriend Stefan Chambers, her brother Daniel McVey and his girlfriend Kate Coleman. On the next day, she sees herself driving a car on the street and she follows the woman to her apartment, where she finds a picture of her father and her. While driving back, she has a car crash and loses parts of her memory; further, she believes Stefan is another man. Gina decides to investigate what is happening and unravels a dark reality.

A young woman leaves her job and lover in Japan to start a new life in Thailand.

In 1965, Ernesto 'Che' Guevara resigns from his Cuban government posts to secretly make his latest attempt to spread the revolution in Bolivia. After arriving in La Paz, Bolivia late in 1966, by 1967, Che with several Cuban volunteers, have raised a small guerrilla army to take on the militarist Bolivian movement. However, Che must face grim realities about his few troops and supplies, his failing health, and a local population who largely does not share his idealistic aspirations. As the US supported Bolivian army prepares to defeat him, Che and his beleaguered force struggle against the increasingly hopeless odds.

When one of the brothers (Ohayn) dies, all the whole family comes for Shiva (Jewish tradition,when the family sits seven days at the home after the death one of their family). A large family with a lot of problems and conflicts between them.