It's graduation weekend, and Sandy Channing, the popular class president of her small-town high school, should be enjoying the time of her life. But when her friends start disappearing, Sandy discovers they have unwittingly awakened the vengeful spirit of a girl they wronged long ago. Fighting for her sanity, Sandy must unlock a dark secret from her own past before it's too late.

Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device.

Beautiful, seductive rich girl Daphne gets her kicks playing mind games; finding and seducing young working-class men until she cruelly kicks them to the curb. But when she comes across handsome med student Nick, she discovers a challenge. Nick isn't so easily seduced. So Daphne and her friends set about seducing Nick's girlfriend, Heather. When things go wrong and Heather gets in a terrible accident, Daphne finds her comfortable easy world spiraling quickly out of control, and it will take all of her ability to find out who is in control of this dangerous game.

Southern Texas. Savannah and Cooper, a young couple in love, drive through the desert in a black 70s Cadillac convertible. Unaware that they are being followed, they check into a motel at the Mexican border. When Savannah leaves to buy food, a cop sneaks into the room, pulls his gun on Cooper, accuses him of murder and tries to arrest him. But Savannah, who had become suspicious, manages to turn the tables: She surprises the cop, ties him up and frees Cooper. But just as the young lovers jump into their car, a stranger steps out of the shadows and kills Cooper at point blank... Three weeks later. Hollywood, California. In a hotel suite overlooking the Sunset Strip, a man is being water boarded by a private detective. The information he needs is: "Who killed Babyface?" When the man refuses to cooperate and shows nothing but contempt for his captor, the torture continues. Layer by layer...