Sprawling epic which follows the Prescotts, an emigrant family through four generations, from the Erie Canal in the 1830's to their settled home in the West a half a century later. On the way they encounter river pirates, and escape with the help of fur trapper Linus Rawlings, who subsequently marries one of their daughters, Eve. The parents are drowned on a foundering raft, and the other daughter Lilith becomes a riverboat singer and catches the eye of a genteel adventurer Cleve Van Valen. They cross the plains together in a wagon train and make and lose a fortune in California; meanwhile Linus has turned farmer and, comes the Civil War, joins the Union Army and is killed at the Battle of Shiloh. One of his sons Zeb also joins the army and stays after the war as a cavalry officer and is sent to Colorado to help guard the pioneering railroad against the Indians, whose land they are crossing...

Beginning just after the bloody Sioux victory over General Custer at Little Big Horn, Bury My Heart at Wounded Knee intertwines the perspectives of three characters: Charles Eastman, né Ohiyesa, a young, Dartmouth-educated, Sioux doctor held up as living proof of the alleged success of assimilation; Sitting Bull, the proud Lakota chief who refuses to submit to U.S. government policies designed to strip his people of their identity, their dignity and their sacred land - the gold-laden Black Hills of the Dakotas; and Senator Henry Dawes, who was one of the architects of the government policy on Indian affairs. While Eastman and patrician schoolteacher Elaine Goodale work to improve life for the Indians on the reservation, Senator Dawes lobbies President Grant for more humane treatment, opposing the bellicose stance of General William Tecumseh Sherman. Hope rises for the Indians in the form of the prophet Wovoka and the Ghost Dance...

A Michigan farmer and a prospector form a partnership in the California gold country. Their adventures include buying and sharing a wife, hijacking a stage, kidnaping six prostitutes, and turning their mining camp into a boomtown. Along the way there is plenty of drinking, gambling, and singing. They even find time to do some creative gold mining.

Fearless gunslinger, Lucky Luke, is ordered by the President to bring peace to Daisy Town.

Gene returns from the East with new ranch owner Tom Bennett to find everyone's cattle dying. Blaine has reopened the copper mine and the waste is poisoning the water supply. While Gene is away Tom confronts the miners and a men is killed in the ensuing gunfight. Now Gene not only has the dying cattle problem but his ranch owner is in jail.

Two brothers, Phil and Ted Stoneman, visit their friends in Piedmont, South Carolina: the family Cameron. This friendship is affected by the Civil War, as the Stonemans and the Camerons must join up opposite armies. The consequences of the War in their lives are shown in connection to major historical events, like the development of the Civil War itself, Lincoln's assassination, and the birth of the Ku Klux Klan.

A Mexican crime lord is forced by his mother to plan a suicidal rescue mission to find his lost brother in the most unexpected place on Earth...

Dempsey Rae, a cowboy with no clear aim in life, winds up working on a spread with a hard lady owner just arrived from the East. She needs a tough new top hand and uses all her means of persuasion to get Rae to take the job. But he doesn't like the way the other settlers are getting treated and starts to side with them, despite their introduction of the barbed wire he loathes.