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Graduate of Yale Drama School.Son of producer Louis Melamed. Father was right-hand-man to television pioneer Nat Hiken and producer of many early shows, including Car 54, Where Are You?, Sgt. Bilko and others.Has twin sons with autism. Active, with wife Leslee, as an advocate for families with whose lives are affected by Autism Spectrum Disorder.Is a prominent voice actor. Has dubbed several other actors' entire performances, including villain Don Cabeza, in Roland Joffe's 1986 The Mission, with Robert De Niro.Was adopted. Biological mother is actor/director Nancy Zala. Related, by his biological father, a psychoanalyst, to renowned acting family the Adlers, including Luther & Stella Adler.Immediately after drama school, became an actor in Minneapolis' famed Guthrie Theatre Company.Appeared on Broadway in Amadeus.Was an original member of Western Massachusetts' Shakespeare & Co.Was an instructor at legendary performing arts camp, Stagedoor Manor.While still in high school, played lead guitar on record of hit song Puppet On A String, performed by Miami vocalist Sharon Facente.Was named by Empire Magazine as "One Of The Best Coen Bros. Characters Of All Time.".When Ethan Coen was asked which of the many characters he has created he was proudest of, he responded, "Sy Ableman. Fred Melamed's character from A Serious Man. The best movie monster ever.".In a Hollywood Reporter piece titled "The Best And The Brightest Choose The Best And The Brightest", 2010 Best Actor Oscar winner Jeff Bridges was asked to name his personal favorite performance of the year. His reply: "I got a kick out of Fred Melamed who played Sy Ableman, the guy who steals the wife in A Serious Man...".