After their adventure at Bernie's weekend house (events of "Weekend At Bernie's") accountants/programmers oafish Larry and up-tight Richard return to New York only to be blamed by the insurance company they all worked for Bernie's theft of two million dollars and fired. Larry and Richard investigate and discover that the money is somewhere in St Thomas in the Virgin Islands. Meanwhile the Cartel Bernie was stealing the money for hires a Voodoo Queen to help them find the money. She tells Henry...

Two young men are trying to make their way in a corporation. One on charm, the other on hard work. When they go to the president (Bernie) with a serious financial error on a printout, he pretends to be thrilled and invites them to his beach house for the weekend. He actually plans on having them killed. Bernie is also fooling around with the girlfriend of his mafia partner. When the partner has Bernie killed, the boys end up having to pretend Bernie is still alive as the frustrated hit man tries...