Winsor Z. McCay bets another cartoonist that he can animate a dinosaur. So he draws a big friendly herbivore called Gertie. Then he get into his own picture. Gertie walks through the picture, eats a tree, meets her creator, and takes him carefully on her back for a ride.

Ojo and Unc Nunkie are out of food, so they decide to journey to the Emerald City where they will never starve. Along the way, they meet Mewel, a waif and stray (mule) who leads them to Dr. Pipt, who has been stirring the powder of life for nine years. Ojo adds plenty of brains to Margolotte's Patchwork servant before she is brought to life with the powder. When Scraps does come to life, she accidentally knocks the liquid of petrifaction upon Unc Nunkie, Margolotte, and Danx (daughter Jesseva's boyfriend). So all go on separate journeys to find the ingredients to the antidote. (Of course Jesseva has Danx shrunken to take with her, which causes trouble with Jinjur.) Of course, no one ever told Ojo that some of the ingredients were illegal to obtain...

Fatty steals a ride on a train, discovered, and put off in the middle of nowhere. He stumbles along over the hot desert and finally passes out. A very plump Indian woman finds him and takes him to her tepee, woos him and finally, in desperation, Fatty agrees to marry her. While the tribe is preparing for the marriage ceremony, Fatty attempts to escape but is caught.

Captain Wynnegate leaves England, accepting the blame for embezzling charity funds though knowing that his cousin Sir Henry is guilty. Out West he and the Indian girl Nat-U-Rich save each other from the evil cattle rustler Cash Hawkins and marry. Lady Diana shows up to announce Sir Henry's death. After Nat-U-Rich's suicide Wynnegate takes his half-breed son and Lady Diana back to England as the new Earl of Kerhill.