Awkward teen Scott McCall's life changes forever when he is bitten by a werewolf and becomes one himself. Some changes are positive - increased prowess in sports, super-hearing and a boost in confidence. But there are problems, and dangers, that come along with being a lycanthrope.

Younger brother Nick ( ), who has Asperger's syndrome, struggles to cope and understand after the death of his brother Chaz ( ). His parents are in denial about several things, and are not communicating or dealing well with the loss, but then Chaz's best friend, Randy, decides to become a mentor to Nick.

Marisa Ventura is a single mother born and bred in the boroughs of New York City, who works as a maid in a first-class Manhattan hotel. By a twist of fate and mistaken identity, Marisa meets Christopher Marshall, a handsome heir to a political dynasty, who believes that she is a guest at the hotel. Fate steps in and throws the unlikely pair together for one night. When Marisa's true identity is revealed, the two find that they are worlds apart, even though the distance separating them is just a subway ride between Manhattan and the Bronx.