A dying mother's life lessons to the husband and sons she left behind. Based on the best-selling novel by St John (Singe) Greene, the film is the story of Singe and Kate, a couple from North Somerset, whose lives were turned upside down when Kate was diagnosed with an incurable breast cancer. Over her last few days, she created her list: writing her thoughts and memories down, to help the man she loved create the best life possible for their two sons, after she was gone.

Just before he's to marry Fiona, Roderick Blank receives an anonymous e-mail with 101 names on it; Fiona's is the 29th, the first 28 are women Rod has slept with, and the 30th turns out to be the stripper at his bachelor party. The notion that he will have sex with 70 more people sends Rod into crisis mode, especially after three odd men in an aseptic office confirm that a celestial machine has made an error. They suggest destroying the list, but Rod finds that easier said than done. Working his way through it consumes him, plus he realizes that death may await him after #101. Meanwhile, a femme fatale nicknamed Death Nell is putting men into a coma. Are they fated to meet?